{"counters":{"open":1943,"resolved":2,"pending":1,"theories":39,"forecasters":3},"live":{"active_forecasters":1,"writes_24h":32,"resolutions_24h":2,"requests_60s":0,"requests_total":0},"activity":[{"kind":"theory","theory":"thy_ad11659fd84d14d5","question":"NCT05929664#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:19Z"},{"kind":"theory","theory":"thy_de009fc3a6a2d892","question":"NCT07567469#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:19Z"},{"kind":"theory","theory":"thy_a678b63d1be4aea9","question":"NCT05987241#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:18Z"},{"kind":"theory","theory":"thy_01513c80049e12a7","question":"NCT07281924#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:18Z"},{"kind":"theory","theory":"thy_bf12b76f706adcf0","question":"NCT06715241#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:18Z"},{"kind":"theory","theory":"thy_863eecec8801174c","question":"NCT05785767#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:17Z"},{"kind":"theory","theory":"thy_4d8dfe8de361a6c0","question":"NCT06205836#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:17Z"},{"kind":"theory","theory":"thy_dd8d01ab8c599f42","question":"NCT06561386#primary-endpoint-met","target":"LAG3","direction":"fail","p":0.35,"ts":"2026-05-31T17:36:17Z"}],"mechanisms_scoring":[{"tags":["target:Nectin-4 + CTLA-4 + PD-L1","pathway:immune-synapse + priming + direct-cytotoxicity","moa:multi-step-coverage","failure_mode:none"],"n":1,"weight":1.0},{"tags":["target:LAG3","pathway:antigen-presentation","moa:checkpoint-inhibition","failure_mode:none"],"n":1,"weight":0.0}],"questions":[{"id":"NCT07243951#primary-endpoint-met","nct":"NCT07243951","indication":"Combined Hepatocellular-cholangiocarcinoma","phase":"2","drug":"Cadonilimab","resolves_by":"2026-12-31"},{"id":"NCT04443543#primary-endpoint-met","nct":"NCT04443543","indication":"Rectal Cancer","phase":"2","drug":"Capecitabine (Xeloda) Pharmacogenetic Test Reagents","resolves_by":"2026-06-30"},{"id":"NCT07466927#primary-endpoint-met","nct":"NCT07466927","indication":"HER2-negative Breast Cancer","phase":"2","drug":"SHR-A1811","resolves_by":"2028-01-15"},{"id":"NCT06843434#primary-endpoint-met","nct":"NCT06843434","indication":"Microsatellite Stable Rectal Carcinoma","phase":"2","drug":"Balstilimab","resolves_by":"2028-02-20"},{"id":"NCT06823479#primary-endpoint-met","nct":"NCT06823479","indication":"Cutaneous Squamous Cell Carcinoma (CSCC)","phase":"2","drug":"Nivolumab","resolves_by":"2029-02"},{"id":"NCT07007767#primary-endpoint-met","nct":"NCT07007767","indication":"Colorectal Cancer Metastatic","phase":"2","drug":"sintilimab","resolves_by":"2026-12-30"},{"id":"NCT05312671#primary-endpoint-met","nct":"NCT05312671","indication":"Small Cell Neuroendocrine Carcinoma of Bladder","phase":"2","drug":"Atezolizumab","resolves_by":"2027-10"},{"id":"NCT07328503#primary-endpoint-met","nct":"NCT07328503","indication":"Acute Lymphoblastic Leukemia","phase":"2","drug":"CD22 CAR-transduced T cells","resolves_by":"2030-01-31"},{"id":"NCT07419880#primary-endpoint-met","nct":"NCT07419880","indication":"Triple -Negative Breast Cancer","phase":"2","drug":"Cromolyn, TQB2102, and Panpulimab","resolves_by":"2027-01-30"},{"id":"NCT06747845#primary-endpoint-met","nct":"NCT06747845","indication":"Pancreatic Adenocarcinoma Metastatic","phase":"2","drug":"Niraparib","resolves_by":"2028-06"},{"id":"NCT06173219#primary-endpoint-met","nct":"NCT06173219","indication":"Advanced Solid Tumor","phase":"1/2","drug":"Radiotherapy combined with immunotherapy","resolves_by":"2026-07-31"},{"id":"NCT06771518#primary-endpoint-met","nct":"NCT06771518","indication":"Small Cell Lung Cancer","phase":"2","drug":"Thoracic radiotherapy","resolves_by":"2026-12-15"},{"id":"NCT06240143#primary-endpoint-met","nct":"NCT06240143","indication":"Melanoma","phase":"1/2","drug":"Ipilimumab","resolves_by":"2029-07"},{"id":"NCT04671667#primary-endpoint-met","nct":"NCT04671667","indication":"Recurrent Head and Neck Squamous Cell Carcinoma","phase":"2","drug":"Carboplatin","resolves_by":"2029-06-30"},{"id":"NCT07408635#primary-endpoint-met","nct":"NCT07408635","indication":"Unresectable Stage III Non-small Cell Lung Cancer","phase":"2","drug":"IBI363 + Chemotherapy","resolves_by":"2028-06-06"},{"id":"NCT07001618#primary-endpoint-met","nct":"NCT07001618","indication":"NSCLC (Advanced Non-small Cell Lung Cancer)","phase":"2","drug":"MaaT033 capsule","resolves_by":"2030-09"},{"id":"NCT06719700#primary-endpoint-met","nct":"NCT06719700","indication":"Toripalimab","phase":"2","drug":"Chemotherapy","resolves_by":"2028-11-29"},{"id":"NCT07467863#primary-endpoint-met","nct":"NCT07467863","indication":"Non-Small Cell Lung Cancer","phase":"1/2","drug":"Dual-target CAR-NK cells","resolves_by":"2027-02-14"},{"id":"NCT07241819#primary-endpoint-met","nct":"NCT07241819","indication":"II-IIIB (T3N2) Resectable Non-small Cell Lung Cancer","phase":"2","drug":"Ivonescimab/surgery","resolves_by":"2027-11-30"},{"id":"NCT05475613#primary-endpoint-met","nct":"NCT05475613","indication":"Liver Transplantation","phase":"2","drug":"Downstaging procedures containing immunotherapy","resolves_by":"2027-08-01"},{"id":"NCT06013618#primary-endpoint-met","nct":"NCT06013618","indication":"Neuroblastoma","phase":"2","drug":"Naxitamab monotherapy","resolves_by":"2026-12-31"},{"id":"NCT06830239#primary-endpoint-met","nct":"NCT06830239","indication":"Colon Cancer Stage III","phase":"2","drug":"Dostarlimab","resolves_by":"2027-12"},{"id":"NCT07036380#primary-endpoint-met","nct":"NCT07036380","indication":"Advanced Biliary Tract Carcinoma","phase":"2","drug":"MP0317 + Gemcitabine + Cisplatine + Durvalumab","resolves_by":"2028-11"},{"id":"NCT06891521#primary-endpoint-met","nct":"NCT06891521","indication":"Cancer","phase":"2","drug":"Electroacupuncture","resolves_by":"2027-03-01"}]}